Tra i due litiganti… il terzo gode

29 03 2009

 





runonce

23 03 2009





organizzazione

16 03 2009




Alterazione dell’espressione genetica nel tessuto adiposo

11 03 2009

Nutrients regulate metabolic fluxes and homeostasis through transcriptional and translational
control of enzyme concentrations and allosteric modulation of enzyme activity. Dietary u-3
polyunsaturated fatty acids (PUFAs) have been shown to exert a variety of beneficial health effects
such as reducing adiposity and increasing insulin sensitivity in rodents. It is now clear that PUFAs
regulate fundamental adipose cell and liver functions through modulation of activity and
abundance of key transcription factors that act as nutrient sensors, including peroxisome
proliferator-activated receptors (PPARa/d/g), sterol regulatory element binding proteins (SREBP-
1/2), and liver X receptors (LXRa/b). However, in the state of obesity, where adipose tissue
shows elevated storage of triglycerides, many lipogenic genes that are essential for adipose cell
function including PPARg, SREBP-1c, CCAAT-enhancer binding protein a and stearoyl-CoA
desaturase-1 are downregulated, apparently due to desensitization of the very same crucial
nutrient sensors. This chapter will summarize recent studies of PUFA- and obesity-induced
changes in gene expression in white adipose tissue.





sedicendo

26 01 2009


È finita un’altra settimana, la domenica se n’è andata senza che te ne rendessi conto e non hai combinato un cazzo. Non hai voglia di andare a dormire perchè sai che domani quando ti sveglierai non avrai voglia di alzarti, ti aspetta un lunedì di merda che sarà solo l’inizio di una settimana d’inferno.





need to switch

23 01 2009




il primo della classe

20 01 2009